Timing and severity of community acquired respiratory virus infections after myeloablative versus non-myeloablative hematopoietic stem cell transplantation

摘要

Respiratory virus infections are important causes of morbidity and mortality after hematopoietic cell transplantation. Their clinical course can be severe with progression to lower respiratory tract infection, co-infection with serious pulmonary co-pathogens, and high mortality. The findings of this retrospective cohort study indicate that viral lower respiratory tract infection during the first 100 days after hematopoietic cell transplantation was less common among patients undergoing non-myeloablative conditioning regimens than in those receiving myeloablative conditioning, despite a similar overall rate of acquisition.